Ontology highlight
ABSTRACT:
SUBMITTER: Bisignano P
PROVIDER: S-EPMC4703110 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Bisignano Paola P Burford Neil T NT Shang Yi Y Marlow Brennica B Livingston Kathryn E KE Fenton Abigail M AM Rockwell Kristin K Budenholzer Lauren L Traynor John R JR Gerritz Samuel W SW Alt Andrew A Filizola Marta M
Journal of chemical information and modeling 20150915 9
With the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the opioid receptors. In the past two years, the first chemotypes of positive or silent allosteric modulators (PAMs or SAMs, respectively) of μ- and δ-opioid receptor types have been reported in the literature. During a structure-guided lead optimization campaign with μ-PAMs BMS-986121 and BMS-986122 as starting compounds, we discovered a new chemotype that was co ...[more]