Ontology highlight
ABSTRACT:
SUBMITTER: Moon PM
PROVIDER: S-EPMC4703322 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Moon Paxton M PM Penuela Silvia S Barr Kevin K Khan Sami S Pin Christopher L CL Welch Ian I Attur Mukundan M Abramson Steven B SB Laird Dale W DW Beier Frank F
Journal of molecular medicine (Berlin, Germany) 20150704 8
<h4>Unlabelled</h4>Osteoarthritis (OA) is a highly prevalent, disabling joint disease with no existing therapies to slow or halt its progression. Cartilage degeneration hallmarks OA pathogenesis, and pannexin 3 (Panx3), a member of a novel family of channel proteins, is upregulated during this process. The function of Panx3 remains poorly understood, but we consistently observed a strong increase in Panx3 immunostaining in OA lesions in both mice and humans. Here, we developed and characterized ...[more]