Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4703367 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Li Xuefeng X He Sisi S Zhou Xikun X Ye Yan Y Tan Shirui S Zhang Shuang S Li Rongpeng R Yu Min M Jundt Michael C MC Hidebrand Alec A Wang Yongsheng Y Li Guoping G Huang Canhua C Wu Min M
PLoS pathogens 20160106 1
Extracellular bacteria, such as Pseudomonas aeruginosa and Klebsiella pneumoniae, have been reported to induce autophagy; however, the role and machinery of infection-induced autophagy remain elusive. We show that the pleiotropic Src kinase Lyn mediates phagocytosis and autophagosome maturation in alveolar macrophages (AM), which facilitates eventual bacterial eradication. We report that Lyn is required for bacterial infection-induced recruitment of autophagic components to pathogen-containing p ...[more]