A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva.
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ABSTRACT:
SUBMITTER: Kawahara R
PROVIDER: S-EPMC4703492 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva.
Kawahara Rebeca R Bollinger James G JG Rivera César C Ribeiro Ana Carolina P AC Brandão Thaís Bianca TB Paes Leme Adriana F AF MacCoss Michael J MJ
Proteomics 20151215 1
Head and neck cancers, including oral squamous cell carcinoma (OSCC), are the sixth most common malignancy in the world and are characterized by poor prognosis and a low survival rate. Saliva is oral fluid with intimate contact with OSCC. Besides non-invasive, simple, and rapid to collect, saliva is a potential source of biomarkers. In this study, we build an SRM assay that targets fourteen OSCC candidate biomarker proteins, which were evaluated in a set of clinically-derived saliva samples. Usi ...[more]
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