Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.
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ABSTRACT:
SUBMITTER: Pithadia AS
PROVIDER: S-EPMC4703533 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.
Pithadia Amit S AS Bhunia Anirban A Sribalan Rajendran R Padmini Vediappen V Fierke Carol A CA Ramamoorthy Ayyalusamy A
Chemical communications (Cambridge, England) 20160101 5
The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, i ...[more]
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