Amyloid-? adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation.

ABSTRACT: Aggregation at the neuronal cell membrane's lipid bilayer surface is implicated in amyloid-? (A?) toxicity associated with Alzheimer's disease; however, structural and mechanistic insights into the process remain scarce. We have identified a conserved binding mode of A?40 on lipid bilayer surfaces with a conserved helix containing the self-recognition site (K16-E22).

SUBMITTER: Korshavn KJ 

PROVIDER: S-EPMC4703560 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature