Ontology highlight
ABSTRACT:
SUBMITTER: Wong CT
PROVIDER: S-EPMC4703857 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Wong Chi T CT Xu Yingqi Y Gupta Akshari A Garnett James A JA Matthews Steve J SJ Hare Stephen A SA
Nature communications 20151216
The Neisseriaceae family of bacteria causes a range of diseases including meningitis, septicaemia, gonorrhoea and endocarditis, and extracts haem from haemoglobin as an important iron source within the iron-limited environment of its human host. Herein we report crystal structures of apo- and haemoglobin-bound HpuA, an essential component of this haem import system. The interface involves long loops on the bacterial receptor that present hydrophobic side chains for packing against the surface of ...[more]