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Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria.

ABSTRACT: Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.

SUBMITTER: Lee JY

PROVIDER: S-EPMC4704156 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria.

Lee Ji-Young JY Choi Myung-Jin MJ Choi Hyeon Jin HJ Ko Kwan Soo KS

Antimicrobial agents and chemotherapy 20151012 1

Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants wer ...[more]

PMID: 26459897

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Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

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