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Carriage of Enterobacteria Producing Extended-Spectrum ?-Lactamases and Composition of the Gut Microbiota in an Amerindian Community.


ABSTRACT: Epidemiological and individual risk factors for colonization by enterobacteria producing extended-spectrum beta-lactamases (E-ESBL) have been studied extensively, but whether such colonization is associated with significant changes in the composition of the rest of the microbiota is still unknown. To address this issue, we assessed in an isolated Amerindian Guianese community whether intestinal carriage of E-ESBL was associated with specificities in gut microbiota using metagenomic and metatranscriptomic approaches. While the richness of taxa of the active microbiota of carriers was similar to that of noncarriers, the taxa were less homogeneous. In addition, species of four genera, Desulfovibrio, Oscillospira, Parabacteroides, and Coprococcus, were significantly more abundant in the active microbiota of noncarriers than in the active microbiota of carriers, whereas such was the case only for species of Desulfovibrio and Oscillospira in the total microbiota. Differential genera in noncarrier microbiota could either be associated with resistance to colonization or be the consequence of the colonization by E-ESBL.

SUBMITTER: Gosalbes MJ 

PROVIDER: S-EPMC4704183 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Carriage of Enterobacteria Producing Extended-Spectrum β-Lactamases and Composition of the Gut Microbiota in an Amerindian Community.

Gosalbes María José MJ   Vázquez-Castellanos Jorge F JF   Angebault Cécile C   Woerther Paul-Louis PL   Ruppé Etienne E   Ruppé Etienne E   Ferrús María Loreto ML   Latorre Amparo A   Andremont Antoine A   Moya Andrés A  

Antimicrobial agents and chemotherapy 20151109 1


Epidemiological and individual risk factors for colonization by enterobacteria producing extended-spectrum beta-lactamases (E-ESBL) have been studied extensively, but whether such colonization is associated with significant changes in the composition of the rest of the microbiota is still unknown. To address this issue, we assessed in an isolated Amerindian Guianese community whether intestinal carriage of E-ESBL was associated with specificities in gut microbiota using metagenomic and metatrans  ...[more]

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