Ontology highlight
ABSTRACT:
SUBMITTER: Hennig S
PROVIDER: S-EPMC4704238 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20151019 1
Rifabutin, used to treat HIV-infected tuberculosis, shows highly variable drug exposure, complicating dosing. Effects of SLCO1B1 polymorphisms on rifabutin pharmacokinetics were investigated in 35 African HIV-infected tuberculosis patients after multiple doses. Nonlinear mixed-effects modeling found that influential covariates for the pharmacokinetics were weight, sex, and a 30% increased bioavailability among heterozygous carriers of SLCO1B1 rs1104581 (previously associated with low rifampin co ...[more]