Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.
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ABSTRACT:
SUBMITTER: Powell DA
PROVIDER: S-EPMC4704447 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.
Powell Daniel A DA Roberts Lydia M LM Ledvina Hannah E HE Sempowski Gregory D GD Curtiss Roy R Frelinger Jeffrey A JA
Cellular immunology 20151022
Upon bacterial infection the host cells generate a wide variety of cytokines. Genetic attenuation of bacterial physiological pathogens can be accomplished not only by disruption of normal bacterial processes, but also by the loss of the ability to redirect the host immune system. We examined nine attenuated Salmonella Typhimurium mutants for their ability to replicate as well as the cytokines produced after infection of Bone Marrow Derived Macrophages (BMDM). Infection of BMDM with attenuated Sa ...[more]
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