A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase II?.
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ABSTRACT:
SUBMITTER: Sandhaus S
PROVIDER: S-EPMC4704796 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.
Sandhaus Shayna S Taylor Rosella R Edwards Tiffany T Huddleston Alexis A Wooten Ykeysha Y Venkatraman Ramaiyer R Weber Ralph T RT González-Sarrías Antonio A Martin Patrick M PM Cagle Patrice P Tse-Dinh Yuk-Ching YC Beebe Stephen J SJ Seeram Navindra N Holder Alvin A AA
Inorganic chemistry communications 20160201
A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C<sub>2</sub>H<sub>5</sub>OH <b>1</b> (where acetylethTSC = (<i>E</i>)-<i>N</i>-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. <i>In vitro</i> studies showed that complex <b>1</b> acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects. ...[more]
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