Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4705524 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Li Yuanyuan Y Leneghan Darren B DB Miura Kazutoyo K Nikolaeva Daria D Brian Iona J IJ Dicks Matthew D J MD Fyfe Alex J AJ Zakutansky Sarah E SE de Cassan Simone S Long Carole A CA Draper Simon J SJ Hill Adrian V S AV Hill Fergal F Biswas Sumi S
Scientific reports 20160108
Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination. High-titer functional antibodies are required against target antigens to achieve effective transmission-blocking activity. We have fused Pfs25, the leading malaria TBV candidate antigen to IMX313, a molecular adjuvant and expressed it both in ChAd63 and MVA viral vectors and as a secreted protein-nanoparticle. Pfs2 ...[more]