Ontology highlight
ABSTRACT:
SUBMITTER: Zemora G
PROVIDER: S-EPMC4705647 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zemora Georgeta G Handl Stefan S Waldsich Christina C
Nucleic acids research 20151019 1
Telomerase is a specialized reverse transcriptase that is responsible for telomere length maintenance. As in other organisms, the minimal components required for an active human telomerase are the template-providing telomerase RNA (hTR) and the enzymatic entity telomerase reverse transcriptase (hTERT). Here, we explored the structure of hTR and the hTERT-induced conformational changes within hTR in living cells. By employing an in vivo DMS chemical probing technique, we showed that the pseudokno ...[more]