The 3D folding of metazoan genomes correlates with the association of similar repetitive elements.
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ABSTRACT:
SUBMITTER: Cournac A
PROVIDER: S-EPMC4705657 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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The 3D folding of metazoan genomes correlates with the association of similar repetitive elements.
Cournac Axel A Koszul Romain R Mozziconacci Julien J
Nucleic acids research 20151124 1
The potential roles of the numerous repetitive elements found in the genomes of multi-cellular organisms remain speculative. Several studies have suggested a role in stabilizing specific 3D genomic contacts. To test this hypothesis, we exploited inter-chromosomal contacts frequencies obtained from Hi-C experiments and show that the folding of the human, mouse and Drosophila genomes is associated with a significant co-localization of several specific repetitive elements, notably many elements of ...[more]
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