Ontology highlight
ABSTRACT:
SUBMITTER: Noer SL
PROVIDER: S-EPMC4705662 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Noer Sofie L SL Preus Søren S Gudnason Daniel D Aznauryan Mikayel M Mergny Jean-Louis JL Birkedal Victoria V
Nucleic acids research 20151128 1
G-quadruplex structures can occur throughout the genome, including at telomeres. They are involved in cellular regulation and are potential drug targets. Human telomeric G-quadruplex structures can fold into a number of different conformations and show large conformational diversity. To elucidate the different G-quadruplex conformations and their dynamics, we investigated telomeric G-quadruplex folding using single molecule FRET microscopy in conditions where it was previously believed to yield ...[more]