Identification of large-scale genomic variation in cancer genomes using in silico reference models.
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ABSTRACT:
SUBMITTER: Killcoyne S
PROVIDER: S-EPMC4705683 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of large-scale genomic variation in cancer genomes using in silico reference models.
Killcoyne Sarah S Del Sol Antonio A
Nucleic acids research 20150811 1
Identifying large-scale structural variation in cancer genomes continues to be a challenge to researchers. Current methods rely on genome alignments based on a reference that can be a poor fit to highly variant and complex tumor genomes. To address this challenge we developed a method that uses available breakpoint information to generate models of structural variations. We use these models as references to align previously unmapped and discordant reads from a genome. By using these models to al ...[more]
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