Comparison of human Nrf2 antibodies: A tale of two proteins.
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ABSTRACT:
SUBMITTER: Kemmerer ZA
PROVIDER: S-EPMC4705856 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Comparison of human Nrf2 antibodies: A tale of two proteins.
Kemmerer Zachary A ZA Ader Nicholas R NR Mulroy Sarah S SS Eggler Aimee L AL
Toxicology letters 20150726 2
The Nrf2 transcription factor is a master regulator of the cellular defense against oxidative and electrophilic stress. An increase in Nrf2 protein levels and an accumulation of Nrf2 in the nucleus are key parts of the Nrf2 activation mechanism. The western blot technique remains the most widely used method to assess these changes. A well-characterized, specific antibody that is commercially available would greatly enhance these studies in the field. Here, an apparently highly specific Nrf2 mono ...[more]
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