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Age as an independent prognostic factor for survival of localised synovial sarcoma patients.

ABSTRACT: We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients.Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, and elderly) was estimated by Kaplan-Meier survival curves and multivariable Cox-proportional hazards modelling.A total of 461 patients had localised disease at diagnosis. The 5-year overall survival (OS) was 89.3±4.6%, 73.0±3.8%, 54.7±3.6%, and 43.0±7.0% in children (n=54), AYAs (n=148), adults (n=204), and elderly (n=55), respectively. Treatment modalities had no significant effect on survival in the univariable analysis. Multivariable analysis identified age at diagnosis, tumour localisation, and tumour size as significant factors affecting OS. Both tumour localisation and size were equally distributed over the age groups.We show that outcome of synovial sarcoma patients significantly decreases with age regardless of primary tumour site, size, and treatment.

SUBMITTER: Vlenterie M

PROVIDER: S-EPMC4705887 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Age as an independent prognostic factor for survival of localised synovial sarcoma patients.

Vlenterie Myrella M Ho Vincent K Y VK Kaal Suzanne E J SE Vlenterie Richelle R Haas Rick R van der Graaf Winette T A WT

British journal of cancer 20151110 11

<h4>Background</h4>We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients.<h4>Methods</h4>Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, and elderly) was estimated by Kaplan-Meier survival curves and multivariable Cox-proportional hazards modelling.<h4>Results</h4>A total of 461 patients had localised di ...[more]

PMID: 26554650

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Project description:Background:Inflammation promotes the development of malignancy, while a variety of systemic markers of inflammation predict for worse cancer outcomes including recurrence and survival. Here, we evaluate the prognostic impact of cytokine concentrations, full blood count (FBC) differential ratios, cognitive function and fatigue on survival in patients with localised colorectal cancer (CRC). Patients and methods:Data are from a prospective longitudinal study comparing cognitive function and fatigue in patients with CRC who did (n=173) and did not (n=116) receive adjuvant/neoadjuvant chemotherapy. Baseline blood results (prior to any chemotherapy) included cytokines and FBC from which neutrophil lymphocyte ratio, lymphocyte monocyte ratio, platelet lymphocyte ratio and platelet monocyte ratio were derived. Fatigue was measured with the Functional Assessment of Cancer Therapy-Fatigue subscale and cognitive function by a neuropsychological test battery. Kaplan-Meier methods were used to estimate disease-free survival (DFS) and overall survival (OS). Univariable and multivariable Cox regression analyses were performed to evaluate factors potentially prognostic of outcomes. Results:At a median follow-up of 91.2 months, 227 subjects (79%) are still alive, and 212 (73%) have no evidence of a recurrence. Five-year OS and DFS are 86% (95% CI 81% to 90%) and 77% (95% CI 71% to 82%), respectively. None of the cytokines (interleukin (IL-6), IL-1 and tumour necrosis factor) or differential ratios of blood components, fatigue or cognitive function was statistically related to DFS or OS. Patient educational status (P=0.018), stage of disease (P=0.032), alanine transaminase (P=0.003), lactate dehydrogenase (P=0.008) and carcinoembryonic antigen (P=0.002) were significant as prognostic covariates of OS in univariable analyses, with similar results for DFS. Conclusion:None of the a priori selected markers of inflammation, fatigue or cognitive function was associated with OS or DFS in this cohort of patients. Trial registration number:NCT00188331, Post-results.

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Age as an independent prognostic factor for survival of localised synovial sarcoma patients.

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Age as an independent prognostic factor for survival of localised synovial sarcoma patients.

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