Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease.

ABSTRACT: The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer's disease (AD), suggesting a divergence between these diseases in terms of brain network organization. To fully understand this, we studied functional networks from resting-state functional magnetic resonance imaging in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared with the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD < controls < DLB), and this was also the case for global efficiency (DLB > controls > AD) an

SUBMITTER: Peraza LR 

PROVIDER: S-EPMC4706129 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature