Ontology highlight
ABSTRACT:
SUBMITTER: Niblock M
PROVIDER: S-EPMC4706155 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Niblock Michael M Hortobágyi Tibor T Troakes Claire C Al-Sarraj Safa S Spickett Carl C Jones Rebecca R Shaw Christopher E CE Gallo Jean-Marc JM
Neurobiology of aging 20151009
A proportion of Alzheimer's disease cases displays inclusions of the RNA-binding protein, TDP-43. Considering the pathogenic role of tau mis-splicing, we compared tau isoform expression between Alzheimer's disease cases with or without TDP-43 inclusions. The average ratio of tau isoforms containing or lacking exon 10 (4R/3R ratio) or the total level of tau mRNA was not significantly different between cases with or without TDP-43 pathology in any of the brain regions examined. Although TDP-43 fun ...[more]