Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.
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ABSTRACT:
SUBMITTER: Eberl M
PROVIDER: S-EPMC470652 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
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Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.
Eberl Matthias M Hintz Martin M Jamba Zandraa Z Beck Ewald E Jomaa Hassan H Christiansen Gunna G
Infection and immunity 20040801 8
While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells. ...[more]
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