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The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.

ABSTRACT: Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.

SUBMITTER: Amirian ES 

PROVIDER: S-EPMC4706682 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.

Amirian E Susan ES   Armstrong Georgina N GN   Zhou Renke R   Lau Ching C CC   Claus Elizabeth B EB   Barnholtz-Sloan Jill S JS   Il'yasova Dora D   Schildkraut Joellen J   Ali-Osman Francis F   Sadetzki Siegal S   Johansen Christoffer C   Houlston Richard S RS   Jenkins Robert B RB   Lachance Daniel D   Olson Sara H SH   Bernstein Jonine L JL   Merrell Ryan T RT   Wrensch Margaret R MR   Davis Faith G FG   Lai Rose R   Shete Sanjay S   Amos Christopher I CI   Scheurer Michael E ME   Aldape Kenneth K   Alafuzoff Irina I   Brännström Thomas T   Broholm Helle H   Collins Peter P   Giannini Caterina C   Rosenblum Marc M   Tihan Tarik T   Melin Beatrice S BS   Bondy Melissa L ML  

American journal of epidemiology 20151210 2

Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from mul  ...[more]

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