Ontology highlight
ABSTRACT:
SUBMITTER: Liu ML
PROVIDER: S-EPMC4706770 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Liu Meng-Lu ML Zang Tong T Zhang Chun-Li CL
Cell reports 20151224 1
Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Here, we show that adult human skin fibroblasts can be directly and efficiently converted into highly pure motor neurons without passing through an induced pluripotent stem cell stage. These adult human induced motor neurons (hiMNs) exhibit the cytological and electrophysiological features of spinal motor neurons and form functional neuromuscul ...[more]