Ontology highlight
ABSTRACT:
SUBMITTER: Haeri M
PROVIDER: S-EPMC4707176 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Haeri Mohammad M Gelowani Violet V Beaudet Arthur L AL
MethodsX 20151202
Pathological copy number variants (CNVs) and point mutations are major genetic causes of hundreds of disorders. Comparative genomic hybridization (CGH) also known as chromosomal microarray analysis (CMA) is the best available tool to detect copy number variations in chromosomal make up. We have optimized several different protocols and introduce a high-throughput approach to perform a cost-effective, fast, high-throughput and high-quality CMA. We managed to reach to high quality arrays with 17 ± ...[more]