Ontology highlight
ABSTRACT:
SUBMITTER: Juillerat A
PROVIDER: S-EPMC4707440 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Juillerat Alexandre A Marechal Alan A Filhol Jean-Marie JM Valton Julien J Duclert Aymeric A Poirot Laurent L Duchateau Philippe P
Scientific reports 20160111
The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers the advantage of a transient CAR T-cell for safety while letting open the possibility of multiple cytotoxicity cycles using a small molecule drug. ...[more]