Ontology highlight
ABSTRACT:
SUBMITTER: Liu HS
PROVIDER: S-EPMC4707476 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Liu Hong-Shuai HS Shi Hai-Lian HL Huang Fei F Peterson Karin E KE Wu Hui H Lan Yun-Yi YY Zhang Bei-Bei BB He Yi-Xin YX Woods Tyson T Du Min M Wu Xiao-Jun XJ Wang Zheng-Tao ZT
Scientific reports 20160111
Inhibition of microglia activation may provide therapeutic treatment for many neurodegenerative diseases. Astragaloside IV (ASI) with anti-inflammatory properties has been tested as a therapeutic drug in clinical trials of China. However, the mechanism of ASI inhibiting neuroinflammation is unknown. In this study, we showed that ASI inhibited microglia activation both in vivo and in vitro. It could enhance glucocorticoid receptor (GR)-luciferase activity and facilitate GR nuclear translocation i ...[more]