Mapping Sub-Second Structure in Mouse Behavior.

ABSTRACT: Complex animal behaviors are likely built from simpler modules, but their systematic identification in mammals remains a significant challenge. Here we use depth imaging to show that 3D mouse pose dynamics are structured at the sub-second timescale. Computational modeling of these fast dynamics effectively describes mouse behavior as a series of reused and stereotyped modules with defined transition probabilities. We demonstrate this combined 3D imaging and machine learning method can be used to unmask potential strategies employed by the brain to adapt to the environment, to capture both predicted and previously hidden phenotypes caused by genetic or neural manipulations, and to systematically expose the global structure of behavior within an experiment. This work reveals that mouse body

SUBMITTER: Wiltschko AB 

PROVIDER: S-EPMC4708087 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature