Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC4709567 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20160112
Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway of cytosolic DNA sensing plays a pivotal role in antiviral defense. We report that the STING activator cGAMP possesses significant antitumor activity in mice by triggering the STING-dependent pathway directly. cGAMP enhances innate immune responses by inducing production of cytokines such as interferon-β, interferon-γ, and stimulating dendritic cells activation, which induces the cross-priming of C ...[more]