Ontology highlight
ABSTRACT:
SUBMITTER: Chen XP
PROVIDER: S-EPMC4709605 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chen Xiao-Peng XP Luo Jun-Sheng JS Tian Ye Y Nie Chen-Lin CL Cui Wei W Zhang Wei-Dong WD
BioMed research international 20151229
<h4>Objective</h4>Heparanase (HPSE) is high-expressed in most malignant tumors including hepatocellular carcinoma (HCC) and promotes cancer cell invasion and migration. The aim of the study is to explore whether HPSE enhances adhesion in metastasis of HCC cells.<h4>Methods</h4>HPSE expressions in human HCC cells were measured with real-time RT-PCR and Western blot analysis. Four recombinant miRNA vectors pcDNATM6.2-GW/EmGFP-miR-HPSE (pmiR-HPSE) were transfected into HCCLM3 cell. HPSE expression ...[more]