Ontology highlight
ABSTRACT:
SUBMITTER: Leon S
PROVIDER: S-EPMC4709743 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
León Silvia S Barroso Alexia A Vázquez María J MJ García-Galiano David D Manfredi-Lozano María M Ruiz-Pino Francisco F Heras Violeta V Romero-Ruiz Antonio A Roa Juan J Schutz Günther G Kirilov Milen M Gaytan Francisco F Pinilla Leonor L Tena-Sempere Manuel M
Scientific reports 20160112
Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable. To dissect out direct vs. indirect effects of kisspeptins on GnRH neurons in vivo, we report herein the detailed reproductive/gonadotropic characterization of a Gpr54 null mouse line with selective re-introduction of Gpr54 expression only in GnRH cells (Gpr54(-/ ...[more]