Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies.

ABSTRACT: In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation. In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound

SUBMITTER: Consalvi S 

PROVIDER: S-EPMC4709771 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature