Ontology highlight
ABSTRACT:
SUBMITTER: Holmes WR
PROVIDER: S-EPMC4710240 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Holmes William R WR Liao Laura L Bement William W Edelstein-Keshet Leah L
Molecular biology of the cell 20150826 22
Wounded cells such as Xenopus oocytes respond to damage by assembly and closure of an array of actin filaments and myosin-2 controlled by Rho GTPases, including Rho and Cdc42. Rho and Cdc42 are patterned around wounds in a characteristic manner, with active Rho concentrating in a ring-like zone inside a larger, ring-like zone of active Cdc42. How this patterning is achieved is unknown, but Rho and Cdc42 at wounds are subject to regulation by other proteins, including the protein kinases C. Speci ...[more]