Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC4710517 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chen Shenghan S Cao Pengxiu P Dong Ningzheng N Peng Jianhao J Zhang Chunyi C Wang Hao H Zhou Tiantian T Yang Junhua J Zhang Yue Y Martelli Elizabeth E EE Naga Prasad Sathyamangla V SV Miller Rachel E RE Malfait Anne-Marie AM Zhou Yiqing Y Wu Qingyu Q
Nature medicine 20150810 9
Hypertension is the most common cardiovascular disease, afflicting >30% of adults. The cause of hypertension in most individuals remains unknown, suggesting that additional contributing factors have yet to be discovered. Corin is a serine protease that activates the natriuretic peptides, thereby regulating blood pressure. It is synthesized as a zymogen that is activated by proteolytic cleavage. CORIN variants and mutations impairing corin activation have been identified in people with hypertensi ...[more]