Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease.
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ABSTRACT:
SUBMITTER: Parks OB
PROVIDER: S-EPMC4710696 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease.
Parks Olivia B OB Pociask Derek A DA Hodzic Zerina Z Kolls Jay K JK Good Misty M
Frontiers in cell and developmental biology 20160113
Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many o ...[more]
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