Sirtuin 1 suppresses nuclear factor ?B induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells.
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ABSTRACT:
SUBMITTER: Ishikawa S
PROVIDER: S-EPMC4710730 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells.
Ishikawa Shingo S Takemitsu Hiroshi H Habara Makoto M Mori Nobuko N Yamamoto Ichiro I Arai Toshiro T
The Journal of veterinary medical science 20150713 12
Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat f ...[more]
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