Sirtuin 1 suppresses nuclear factor ?B induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells.

ABSTRACT: Nuclear factor ?B (NF-?B) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-?B. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-?B in cat fibroblast cells. The up-regulation of NF-?B transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-?B and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells.

SUBMITTER: Ishikawa S 

PROVIDER: S-EPMC4710730 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature