CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.
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ABSTRACT:
SUBMITTER: Wassenaar CA
PROVIDER: S-EPMC4712027 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.
Wassenaar Catherine A CA Zhou Qian Q Tyndale Rachel F RF
Pharmacogenomics 20151215 2
CYP2A6 genotyping is of clinical importance--CYP2A6 gene variants influence nicotine metabolism and are associated with nicotine dependence, cigarettes per day, smoking cessation and the risk for tobacco-associated cancers. CYP2A6 gene variants also influence the metabolism of therapeutic drugs, such as the anticancer agents, tegafur and letrozole. Over the years, CYP2A6 genotyping methods have evolved to incorporate novel gene variants and to circumvent genotyping errors resulting from the high ...[more]
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