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Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda.


ABSTRACT: Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% to 2.23%), which is lower than the published prevalence rates of 1.5%-4% among Ugandan children. There may be protective factors that decrease the risk of RHD in HIV-infected children.

SUBMITTER: Gleason B 

PROVIDER: S-EPMC4712089 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda.

Gleason Brigette B   Mirembe Grace G   Namuyonga Judith J   Okello Emmy E   Lwabi Peter P   Lubega Irene I   Lubega Sulaiman S   Musiime Victor V   Kityo Cissy C   Salata Robert A RA   Longenecker Chris T CT  

Journal of acquired immune deficiency syndromes (1999) 20160201 2


Rheumatic heart disease (RHD) remains highly prevalent in resource-constrained settings around the world, including countries with high rates of HIV/AIDS. Although both are immune-mediated diseases, it is unknown whether HIV modifies the risk or progression of RHD. We performed screening echocardiography to determine the prevalence of latent RHD in 488 HIV-infected children aged 5-18 in Kampala, Uganda. The overall prevalence of borderline/definite RHD was 0.82% (95% confidence interval: 0.26% t  ...[more]

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