Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.
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ABSTRACT:
SUBMITTER: Kempaiah P
PROVIDER: S-EPMC4712101 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.
Kempaiah Prakasha P Davidson Lisa B LB Perkins Douglas J DJ Byrd Thomas F TF
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20130209 6
<h4>Background</h4>Mycobacterium abscessus causes lung infection in patients with cystic fibrosis. M. abscessus stimulates the host innate immune response via TLR2 on respiratory epithelial cells. Signaling through TLR2 requires the formation of TLR2/TLR1 heterodimers on the cell surface.<h4>Methods</h4>The ability of M. abscessus to stimulate the innate immune response of cystic fibrosis CFBE41o- respiratory epithelial cells was measured as expression of HβD2 by RT PCR, and release of IL-8 by E ...[more]
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