Ontology highlight
ABSTRACT:
SUBMITTER: Mascetti VL
PROVIDER: S-EPMC4712187 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Mascetti Victoria L VL Pedersen Roger A RA
Cell stem cell 20151217 1
Pluripotent stem cells are defined by their capacity to differentiate into all three tissue layers that comprise the body. Chimera formation, generated by stem cell transplantation to the embryo, is a stringent assessment of stem cell pluripotency. However, the ability of human pluripotent stem cells (hPSCs) to form embryonic chimeras remains in question. Here we show using a stage-matching approach that human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) have th ...[more]