Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC4712338 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Tang Hao H Fan Xiuqin X Xing Junyue J Liu Zhenyun Z Jiang Bin B Dou Yali Y Gorospe Myriam M Wang Wengong W
Aging 20151201 12
A rise in the levels of the cyclin-dependent kinase (CDK) inhibitor p27KIP1 is important for the growth arrest of senescent cells, but the mechanisms responsible for this increase are poorly understood. Here, we show that the tRNA methyltransferase NSun2 represses the expression of p27 in replicative senescence. NSun2 methylated the 5'-untranslated region (UTR) of p27 mRNA at cytosine C64 in vitro and in cells, thereby repressing the translation of p27. During replicative senescence, increased p ...[more]