Ontology highlight
ABSTRACT:
SUBMITTER: Schedel M
PROVIDER: S-EPMC4712703 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Schedel Michaela M Jia Yi Y Michel Sven S Takeda Katsuyuki K Domenico Joanne J Joetham Anthony A Ning Fangkun F Strand Matthew M Han Junyan J Wang Meiqin M Lucas Joseph J JJ Vogelberg Christian C Kabesch Michael M O'Connor Brian P BP Gelfand Erwin W EW
Nature communications 20160111
Effector CD8(+) T cells convert from IFN-γ(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion to IL-13-producers. Transfer of 1,25D3-treated CD8(+) T cells into sensitized and challenged CD8(+)-deficient recipients fails to restore development of lung allergic responses. 1,25D3 alters vitamin D r ...[more]