Ontology highlight
ABSTRACT:
SUBMITTER: Zdravkovic T
PROVIDER: S-EPMC4712832 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zdravkovic Tamara T Nazor Kristopher L KL Larocque Nicholas N Gormley Matthew M Donne Matthew M Hunkapillar Nathan N Giritharan Gnanaratnam G Bernstein Harold S HS Wei Grace G Hebrok Matthias M Zeng Xianmin X Genbacev Olga O Mattis Aras A McMaster Michael T MT Krtolica Ana A Valbuena Diana D Simón Carlos C Laurent Louise C LC Loring Jeanne F JF Fisher Susan J SJ
Development (Cambridge, England) 20151019 23
Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell embryo from a single couple. Compared with numerous conventional lines from blastocysts, they had unique gene expression and DNA methylation patterns that were, in part, indicative of trophoblast competence. At a transcriptional level, UCSFB lines fro ...[more]