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High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome.


ABSTRACT: To evaluate the relationship between metabolic syndrome (MetS) and the prevalence of diabetic retinopathy (DR).We conducted a case-controlled study, with data obtained from 2,551 Chinese participants between 18-79 years of age (representing a population of 1,660,500 in a district of Beijing). 74 cases of DR were found following data assessment by two 45° digital retinal images. Subjects without DR (NDR group) selected from the remaining 2,477 subjects were matched 1:1 to the DR group by HbA1c. MetS was defined by incorporating diagnostic criteria of the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF).There were no statistical differences between the DR group and NDR group in a number of biological or laboratory tests. However, the percentage of patients with DR increased vs. patients without DR with the number of MetS components from 1 to 5 (14.3% vs. 85.7%, 38.9% vs. 61.1%, 49.1% vs. 50.9%, 61.4% vs. 38.6% and 83.3% vs. 16.7%, respectively) (Pearson ?2 = 9.938, P = 0.037). The trend to develop DR with MetS was significantly higher than that without MetS (NMetS) (?2 = 5.540, P = 0.019). MetS was an independent statistical indicator of the presence of DR after adjusting for age and sex [odds ratio (95% CI): 2.701(1.248-5.849), P = 0.012], which is still the case with an additional adjustment for WC, SBP, TC, HbA1c and duration of diabetes [odds ratio (95% CI): 2.948(1.134-7.664), P = 0.027].DR is one of the diabetic microvascular complications. Apart from poor glycemic control, the concomitance of other metabolic factors can also influence DR. MetS, defined as a cluster of metabolic risk factors, is a strong and independent indicator of DR, even to the same extent as glycemic control.

SUBMITTER: Gao L 

PROVIDER: S-EPMC4712887 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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High Prevalence of Diabetic Retinopathy in Diabetic Patients Concomitant with Metabolic Syndrome.

Gao Lu L   Xin Zhong Z   Yuan Ming-Xia MX   Cao Xi X   Feng Jian-Ping JP   Shi Jing J   Zhu Xiao-Rong XR   Yang Jin-Kui JK  

PloS one 20160108 1


<h4>Objective</h4>To evaluate the relationship between metabolic syndrome (MetS) and the prevalence of diabetic retinopathy (DR).<h4>Research design and methods</h4>We conducted a case-controlled study, with data obtained from 2,551 Chinese participants between 18-79 years of age (representing a population of 1,660,500 in a district of Beijing). 74 cases of DR were found following data assessment by two 45° digital retinal images. Subjects without DR (NDR group) selected from the remaining 2,477  ...[more]

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