Ontology highlight
ABSTRACT:
SUBMITTER: Dawicki-McKenna JM
PROVIDER: S-EPMC4712911 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Dawicki-McKenna Jennine M JM Langelier Marie-France MF DeNizio Jamie E JE Riccio Amanda A AA Cao Connie D CD Karch Kelly R KR McCauley Michael M Steffen Jamin D JD Black Ben E BE Pascal John M JM
Molecular cell 20151125 5
Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD(+) to regulate multiple cellular processes. DNA breaks sharply elevate PARP-1 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is associated with cell death. The mechanism for tight control of the robust catalytic potential of PARP-1 remains unclear. By monitoring PARP-1 dynamics using hydrogen/deuterium exch ...[more]