Ontology highlight
ABSTRACT:
SUBMITTER: Federico MB
PROVIDER: S-EPMC4712966 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Federico María Belén MB Vallerga María Belén MB Radl Analía A Paviolo Natalia Soledad NS Bocco José Luis JL Di Giorgio Marina M Soria Gastón G Gottifredi Vanesa V
PLoS genetics 20160114 1
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork collapse at ICLs. While lesions different from ICLs can also trigger fork collapse, the contribution of FANCD2 to the resolution of replication-coupled DSBs generated independently from ICLs is unknown. Intriguingly, FANCD2 is readily activated af ...[more]