Ontology highlight
ABSTRACT:
SUBMITTER: Ito H
PROVIDER: S-EPMC4713149 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ito Hiromitsu H Tanaka Shinji S Akiyama Yoshimitsu Y Shimada Shu S Adikrisna Rama R Matsumura Satoshi S Aihara Arihiro A Mitsunori Yusuke Y Ban Daisuke D Ochiai Takanori T Kudo Atsushi A Arii Shigeki S Yamaoka Shoji S Tanabe Minoru M
PloS one 20160114 1
Patients with pancreatic cancer typically develop tumor invasion and metastasis in the early stage. These malignant behaviors might be originated from cancer stem cells (CSCs), but the responsible target is less known about invisible CSCs especially for invasion and metastasis. We previously examined the proteasome activity of CSCs and constructed a real-time visualization system for human pancreatic CSCs. In the present study, we found that CSCs were highly metastatic and dominantly localized a ...[more]