Unknown

Dataset Information

0

Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension.


ABSTRACT: Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P<0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate (P<0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P<0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.

SUBMITTER: Durgan DJ 

PROVIDER: S-EPMC4713369 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension.

Durgan David J DJ   Ganesh Bhanu P BP   Cope Julia L JL   Ajami Nadim J NJ   Phillips Sharon C SC   Petrosino Joseph F JF   Hollister Emily B EB   Bryan Robert M RM  

Hypertension (Dallas, Tex. : 1979) 20151228 2


Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressu  ...[more]

Similar Datasets

2012-09-01 | E-GEOD-38792 | biostudies-arrayexpress
2012-09-01 | GSE38792 | GEO
2023-08-30 | GSE181270 | GEO
| S-EPMC6636426 | biostudies-literature
| S-EPMC5989129 | biostudies-literature
| S-EPMC6236151 | biostudies-other
| S-EPMC7099180 | biostudies-literature
| S-EPMC8651365 | biostudies-literature
| S-EPMC7803107 | biostudies-literature
| S-EPMC7849667 | biostudies-literature