Multiscale modeling of tumor growth induced by circadian rhythm disruption in epithelial tissue.
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ABSTRACT:
SUBMITTER: Bratsun DA
PROVIDER: S-EPMC4713406 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Multiscale modeling of tumor growth induced by circadian rhythm disruption in epithelial tissue.
Bratsun D A DA Merkuriev D V DV Zakharov A P AP Pismen L M LM
Journal of biological physics 20150821 1
We propose a multiscale chemo-mechanical model of cancer tumor development in epithelial tissue. The model is based on the transformation of normal cells into a cancerous state triggered by a local failure of spatial synchronization of the circadian rhythm. The model includes mechanical interactions and a chemical signal exchange between neighboring cells, as well as a division of cells and intercalation that allows for modification of the respective parameters following transformation into the ...[more]
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