Association between CTLA-4 rs231775 polymorphism and hepatocellular carcinoma susceptibility.

ABSTRACT:

Aims

Our study aimed to investigate the association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) rs231775 polymorphism with hepatocellular carcinoma (HCC) susceptibility.

Methods

Genotypes distribution of the control was tested by Hardy-Weinberg Equilibrium (HWE). CTLA-4 rs231775 polymorphism was analyzed in 80 patients with HCC and 78 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the expression level of CTLA-4 in the serum of all subjects was detected using enzyme linked immunosorbent assay (ELISA) kit. Odd ratio (OR) with 95% confidence interval (CI) were calculated by chi-squared test to determine the correlation of CTLA-4 rs231775 polymorphism and the risk of HCC.

Results

The genotypes frequencies of

SUBMITTER: Liu Z 

PROVIDER: S-EPMC4713639 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature